Abstract
Granuloma is a well-known inflammatory condition in veterinary and human medicine. It is a chronic inflammatory reaction triggered by a wide variety of persistent agents, characterized by the recruitment and activation of macrophages, occasionally presenting areas of central necrosis. The aim of the present report is to provide information regarding the manifestation, cytology, histology and management of granuloma in sheep. A five-year-old Uda ewe was presented to the Veterinary Teaching Hospital, University of Jos in September, 2023, with a large mass around the neck, extending towards the jugular furrow. Following cytological examination of the mass, surgical excision was undertaken under mild sedation (2% Xylazine) and local anaesthesia (1% Lidocaine hydrochloride). The mass was subjected to histopathological examination, while routine wound cleansing and care was instituted with post-operative administration of analgesic, anti-inflammatory agent, antibiotics, multivitamins and tetanus toxoid intramuscularly. Histopathological findings comprised of masses having necrotic centre with sulfur granules, area of macrophages, lymphocyte, plasma cell and zones of fibro-connective tissue with evidence of neo-vascularization and perivascular cuffing supporting the diagnosis of granuloma. Follow-up re-examinations of the Ewe were undertaken every other day with stitches removed on day 12 post-operation following complete apposition of the wound edges. After 14 days of management, the ewe was discharged following normal rectal temperature (39.0ºC), pulse rates (80.0 beats/minute) and respiratory rates (28.0 cycles/minute). Therefore, cases of granuloma could be satisfactorily managed by complete surgical excision with thorough post-operative care.

Key words: Ewe, Granuloma, Macrophages and Neutrophils, Surgical excision, Inflammation