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2025, Vol: 4, Issue: 4
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Original Article
Online Published: 02 Dec 2025
 


Evaluation of the antioxidant effect of follicular fluid glutathione level on intracytoplasmic sperm injection outcomes

Rihab Abbas Ali, Rabab Zahir Al-yasiry, Sahbaa Hafedh Sagban.


Abstract
Background: Antioxidant status in human follicular fluid (FF) surrounding oocytes may be related to the outcomes of intracytoplasmic sperm injection and embryo transfer (ICSI‐ET). So, we here aimed to exam the relationship between antioxidant status in FF in form of total GSH and the outcomes of ICSI‐ET. Methods: A cross-sectional analytical study was done in the center of fertility treatment, Al-Kafeel Superspecialty hospital, Iraq. 102 sub-fertile couples were involved in this study. The time course of the study is from September 2023 to April 2024. FF was obtained from mature follicles at the time of oocyte pick up. The total glutathione (GSH) concentrations was measured. Results: The couples participants were categorized according to pregnancy state to evaluate the precise role of glutathione on pregnancy state and ICSI outcome. First group has significantly a higher number of retrieved oocyte, MII, 2PN, total embryo number, and good quality embryo (P value <0.05). Total follicular fluid GSH levels were significantly higher in pregnant women after intracytoplasmic sperm injection (ICSI). On grouping the patients according to the cause of infertility, total GSH activity was higher in patients with male factor infertility. Conclusions: Total GSH in human FF may be predictive markers for pregnancy in ART.

Key words: Follicular fluid, glutathione, Antioxidant, intracytoplasmic sperm injection.


 
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How to Cite this Article
Pubmed Style

Ali RA, Al-yasiry RZ, Sagban SH. Evaluation of the antioxidant effect of follicular fluid glutathione level on intracytoplasmic sperm injection outcomes. J Med Res Rev. 2025; 4(4): 132-137. doi:10.5455/JMRR.20250912083521

Web Style

Ali RA, Al-yasiry RZ, Sagban SH. Evaluation of the antioxidant effect of follicular fluid glutathione level on intracytoplasmic sperm injection outcomes. https://www.wisdomgale.com/jmrr/?mno=283397 [Access: December 06, 2025]. doi:10.5455/JMRR.20250912083521

AMA (American Medical Association) Style

Ali RA, Al-yasiry RZ, Sagban SH. Evaluation of the antioxidant effect of follicular fluid glutathione level on intracytoplasmic sperm injection outcomes. J Med Res Rev. 2025; 4(4): 132-137. doi:10.5455/JMRR.20250912083521


Vancouver/ICMJE Style

Ali RA, Al-yasiry RZ, Sagban SH. Evaluation of the antioxidant effect of follicular fluid glutathione level on intracytoplasmic sperm injection outcomes. J Med Res Rev. (2025), [cited December 06, 2025]; 4(4): 132-137. doi:10.5455/JMRR.20250912083521


Harvard Style

Ali, R. A., Al-yasiry, . R. Z. & Sagban, . S. H. (2025) Evaluation of the antioxidant effect of follicular fluid glutathione level on intracytoplasmic sperm injection outcomes. J Med Res Rev, 4 (4), 132-137. doi:10.5455/JMRR.20250912083521


Turabian Style

Ali, Rihab Abbas, Rabab Zahir Al-yasiry, and Sahbaa Hafedh Sagban. 2025. Evaluation of the antioxidant effect of follicular fluid glutathione level on intracytoplasmic sperm injection outcomes. Journal of Medical Research and Reviews, 4 (4), 132-137. doi:10.5455/JMRR.20250912083521


Chicago Style

Ali, Rihab Abbas, Rabab Zahir Al-yasiry, and Sahbaa Hafedh Sagban. "Evaluation of the antioxidant effect of follicular fluid glutathione level on intracytoplasmic sperm injection outcomes." Journal of Medical Research and Reviews 4 (2025), 132-137. doi:10.5455/JMRR.20250912083521


MLA (The Modern Language Association) Style

Ali, Rihab Abbas, Rabab Zahir Al-yasiry, and Sahbaa Hafedh Sagban. "Evaluation of the antioxidant effect of follicular fluid glutathione level on intracytoplasmic sperm injection outcomes." Journal of Medical Research and Reviews 4.4 (2025), 132-137. Print. doi:10.5455/JMRR.20250912083521


APA (American Psychological Association) Style

Ali, R. A., Al-yasiry, . R. Z. & Sagban, . S. H. (2025) Evaluation of the antioxidant effect of follicular fluid glutathione level on intracytoplasmic sperm injection outcomes. Journal of Medical Research and Reviews, 4 (4), 132-137. doi:10.5455/JMRR.20250912083521


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