Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease

Gurdeep Singh; William Cobb; Haven Ward; Arooj Mian; Tien-Anh Tran; Karen Echeverria-Beltran; Mustafa Arain; Armando Rosales

doi:10.5455/CRSM.20240910083638

Case Rep Ser Med. 2024; 1(2): 36-41

doi: 10.5455/CRSM.20240910083638

Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease

Gurdeep Singh, William Cobb, Haven Ward, Arooj Mian, Tien-anh Tran, Karen Echeverria-beltran, Mustafa Arain, Armando Rosales.

Abstract
Introduction: Rosai-Dorfman disease (RDD) is a benign, proliferative disease of non-Langerhans cell histiocytes typically involving lymphoid tissue. Pancreatic involvement is extremely rare.
Case Description: Our case is of a 53-year-old female who originally presented with vague epigastric abdominal pain. Magnetic resonance imaging (MRI) revealed a mass in the pancreatic body suspicious for malignancy. The patient successfully underwent a robotic-assisted subtotal pancreatectomy and splenectomy. The final pathology revealed sheets of foamy histiocytes with enlarged vesicular nuclei and nucleoli. Immunohistochemical testing was positive for S-100 protein and CD163 and negative for CD1a and ALK-1, establishing a diagnosis of pancreatic Rosai-Dorfman disease. Next generation sequencing was positive for an F53L variant mutation of the MAP2K1 gene.
Discussion: Overall, there is no uniform approach for RDD treatment, treatment is usually tailored to the individual’s clinical picture. Here we describe a novel technique of robotic-assisted resection of pancreatic Rosai-Dorfman disease.

Key words: Rosai-Dorfman Disease; pancreas; robotic subtotal pancreatectomy; histiocytes

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How to Cite this Article

Pubmed Style

Singh G, Cobb W, Ward H, Mian A, Tran T, Echeverria-beltran K, Arain M, Rosales A. Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease. Case Rep Ser Med. 2024; 1(2): 36-41. doi:10.5455/CRSM.20240910083638

Web Style

Singh G, Cobb W, Ward H, Mian A, Tran T, Echeverria-beltran K, Arain M, Rosales A. Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease. https://www.wisdomgale.com/crsm/?mno=219822 [Access: June 07, 2026]. doi:10.5455/CRSM.20240910083638

AMA (American Medical Association) Style

Singh G, Cobb W, Ward H, Mian A, Tran T, Echeverria-beltran K, Arain M, Rosales A. Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease. Case Rep Ser Med. 2024; 1(2): 36-41. doi:10.5455/CRSM.20240910083638

Vancouver/ICMJE Style

Singh G, Cobb W, Ward H, Mian A, Tran T, Echeverria-beltran K, Arain M, Rosales A. Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease. Case Rep Ser Med. (2024), [cited June 07, 2026]; 1(2): 36-41. doi:10.5455/CRSM.20240910083638

Harvard Style

Singh, G., Cobb, . W., Ward, . H., Mian, . A., Tran, . T., Echeverria-beltran, . K., Arain, . M. & Rosales, . A. (2024) Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease. Case Rep Ser Med, 1 (2), 36-41. doi:10.5455/CRSM.20240910083638

Turabian Style

Singh, Gurdeep, William Cobb, Haven Ward, Arooj Mian, Tien-anh Tran, Karen Echeverria-beltran, Mustafa Arain, and Armando Rosales. 2024. Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease. Case Reports and Series in Medicine, 1 (2), 36-41. doi:10.5455/CRSM.20240910083638

Chicago Style

Singh, Gurdeep, William Cobb, Haven Ward, Arooj Mian, Tien-anh Tran, Karen Echeverria-beltran, Mustafa Arain, and Armando Rosales. "Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease." Case Reports and Series in Medicine 1 (2024), 36-41. doi:10.5455/CRSM.20240910083638

MLA (The Modern Language Association) Style

Singh, Gurdeep, William Cobb, Haven Ward, Arooj Mian, Tien-anh Tran, Karen Echeverria-beltran, Mustafa Arain, and Armando Rosales. "Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease." Case Reports and Series in Medicine 1.2 (2024), 36-41. Print. doi:10.5455/CRSM.20240910083638

APA (American Psychological Association) Style

Singh, G., Cobb, . W., Ward, . H., Mian, . A., Tran, . T., Echeverria-beltran, . K., Arain, . M. & Rosales, . A. (2024) Robotic-Assisted Resection of Pancreatic Rosai-Dorfman Disease. Case Reports and Series in Medicine, 1 (2), 36-41. doi:10.5455/CRSM.20240910083638