E-ISSN 2577-2058
 

Case Report
Online Published: 25 Dec 2025
 


Contribution of Hybrid SPECT/CT Dual-Tracer Imaging with Na[⁹⁹ᵐTc]TcO₄ / [⁹⁹ᵐTc]Tc-MIBI in the Diagnosis of a Mediastinal Ectopic Parathyroid Adenoma

Abdel Amide Gbadamassi, Halima Batani, Hafsa Bensimimou, Zakaria Oussafrar, Amal Guensi.


Abstract
Introduction: Primary hyperparathyroidism is the third most common endocrine disorder, affecting women 2 to 3 times more frequently than men. In 80% of cases, it is caused by a parathyroid adenoma. In 15–20% of cases, the parathyroid adenoma is ectopic, resulting from aberrant embryological migration. Mediastinal localization is less common, representing 10–15% of ectopic parathyroid adenomas. Dual-tracer scintigraphy using technetium-sestamibi and technetium pertechnetate improves the sensitivity for detecting parathyroid adenomas. The aim of this study was to demonstrate the contribution of dual-tracer hybrid imaging in the diagnosis of an ectopic parathyroid adenoma.
Case Report: We report a patient whose biological assessment revealed hypercalcemia (11.1 mg/dL) associated with elevated serum parathyroid hormone (PTH) levels (258 pg/mL), suggesting a parathyroid adenoma. Initial cervical ultrasonography failed to identify a suspicious parathyroid lesion. Hybrid SPECT/CT imaging revealed a 12 × 10 mm hypodense nodule located in the right retrosternal region, compatible with a parathyroid adenoma.
Conclusion: The high sensitivity of hybrid imaging allowed the detection of an ectopic parathyroid adenoma and facilitated precise preoperative localization. However, in cases of diagnostic uncertainty, fluorocholine PET/CT has been shown to be more sensitive and more specific.

Key words: Ectopic parathyroid adenoma; Hybrid imaging; SPECT/CT; [⁹⁹ᵐTc]Tc-MIBI; [⁹⁹ᵐTc]TcO₄⁻


 
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How to Cite this Article
Pubmed Style

Gbadamassi AA, Batani H, Bensimimou H, Oussafrar Z, Guensi A. Contribution of Hybrid SPECT/CT Dual-Tracer Imaging with Na[⁹⁹ᵐTc]TcO₄ / [⁹⁹ᵐTc]Tc-MIBI in the Diagnosis of a Mediastinal Ectopic Parathyroid Adenoma. A J Diagn Imaging. 2026; 12(1): 1-5. doi:10.5455/ajdi.20251019063307


Web Style

Gbadamassi AA, Batani H, Bensimimou H, Oussafrar Z, Guensi A. Contribution of Hybrid SPECT/CT Dual-Tracer Imaging with Na[⁹⁹ᵐTc]TcO₄ / [⁹⁹ᵐTc]Tc-MIBI in the Diagnosis of a Mediastinal Ectopic Parathyroid Adenoma. https://www.wisdomgale.com/ajdi/?mno=291448 [Access: January 09, 2026]. doi:10.5455/ajdi.20251019063307


AMA (American Medical Association) Style

Gbadamassi AA, Batani H, Bensimimou H, Oussafrar Z, Guensi A. Contribution of Hybrid SPECT/CT Dual-Tracer Imaging with Na[⁹⁹ᵐTc]TcO₄ / [⁹⁹ᵐTc]Tc-MIBI in the Diagnosis of a Mediastinal Ectopic Parathyroid Adenoma. A J Diagn Imaging. 2026; 12(1): 1-5. doi:10.5455/ajdi.20251019063307



Vancouver/ICMJE Style

Gbadamassi AA, Batani H, Bensimimou H, Oussafrar Z, Guensi A. Contribution of Hybrid SPECT/CT Dual-Tracer Imaging with Na[⁹⁹ᵐTc]TcO₄ / [⁹⁹ᵐTc]Tc-MIBI in the Diagnosis of a Mediastinal Ectopic Parathyroid Adenoma. A J Diagn Imaging. (2026), [cited January 09, 2026]; 12(1): 1-5. doi:10.5455/ajdi.20251019063307



Harvard Style

Gbadamassi, A. A., Batani, . H., Bensimimou, . H., Oussafrar, . Z. & Guensi, . A. (2026) Contribution of Hybrid SPECT/CT Dual-Tracer Imaging with Na[⁹⁹ᵐTc]TcO₄ / [⁹⁹ᵐTc]Tc-MIBI in the Diagnosis of a Mediastinal Ectopic Parathyroid Adenoma. A J Diagn Imaging, 12 (1), 1-5. doi:10.5455/ajdi.20251019063307



Turabian Style

Gbadamassi, Abdel Amide, Halima Batani, Hafsa Bensimimou, Zakaria Oussafrar, and Amal Guensi. 2026. Contribution of Hybrid SPECT/CT Dual-Tracer Imaging with Na[⁹⁹ᵐTc]TcO₄ / [⁹⁹ᵐTc]Tc-MIBI in the Diagnosis of a Mediastinal Ectopic Parathyroid Adenoma. American Journal of Diagnostic Imaging , 12 (1), 1-5. doi:10.5455/ajdi.20251019063307



Chicago Style

Gbadamassi, Abdel Amide, Halima Batani, Hafsa Bensimimou, Zakaria Oussafrar, and Amal Guensi. "Contribution of Hybrid SPECT/CT Dual-Tracer Imaging with Na[⁹⁹ᵐTc]TcO₄ / [⁹⁹ᵐTc]Tc-MIBI in the Diagnosis of a Mediastinal Ectopic Parathyroid Adenoma." American Journal of Diagnostic Imaging 12 (2026), 1-5. doi:10.5455/ajdi.20251019063307



MLA (The Modern Language Association) Style

Gbadamassi, Abdel Amide, Halima Batani, Hafsa Bensimimou, Zakaria Oussafrar, and Amal Guensi. "Contribution of Hybrid SPECT/CT Dual-Tracer Imaging with Na[⁹⁹ᵐTc]TcO₄ / [⁹⁹ᵐTc]Tc-MIBI in the Diagnosis of a Mediastinal Ectopic Parathyroid Adenoma." American Journal of Diagnostic Imaging 12.1 (2026), 1-5. Print. doi:10.5455/ajdi.20251019063307



APA (American Psychological Association) Style

Gbadamassi, A. A., Batani, . H., Bensimimou, . H., Oussafrar, . Z. & Guensi, . A. (2026) Contribution of Hybrid SPECT/CT Dual-Tracer Imaging with Na[⁹⁹ᵐTc]TcO₄ / [⁹⁹ᵐTc]Tc-MIBI in the Diagnosis of a Mediastinal Ectopic Parathyroid Adenoma. American Journal of Diagnostic Imaging , 12 (1), 1-5. doi:10.5455/ajdi.20251019063307