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2025, Vol: 2, Issue: 4
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Original Article
Online Published: 06 Dec 2025
 


Hematological Changes in Albino Rats Following Subacute Exposure to Viva Plus Detergent: Implications for Household Chemical Safety

Aliyu Yahaya Gwiokura, Umar Abdullahi Maina, Emmanuel Oluwasegun Adawaren.


Abstract
Background: The ubiquity of household detergents raises concerns about their potential hematotoxic effects, particularly in populations vulnerable to accidental exposure.
Methods: This investigation examined the hematological consequences of subacute oral administration of Viva Plus detergent in albino rats across three dose tiers (n=5/group: Grp A;1000, Grp B; 2000, and Grp C; 5000 mg/kg bw/day) over a 14-day period starting from 8th to 24nd of July 2025.
Results: The hematological profiling revealed a striking dose-response relationship: leukocyte counts increased progressively from 8.2 ± 1.1 ×10³/μL in controls to 17.9 ×10³/μL at the highest treatment dose (p<0.001) this indicates systemic inflammation due to increase. Concurrently, erythroid parameters exhibited marked suppression, notably with hemoglobin concentration declining by 45% and packed cell volume diminishing from 42.6% to 23.4% at peak dosage (p<0.001). Thrombocyte populations demonstrated significant depletion at ≥2000 mg/kg doses (p<0.05). Notably, erythrocytic indices (MCV, MCH, MCHC) remained within normal range across all the four groups (p>0.8). This suggests normocytic normochromic anemia without cellular morphological alterations.
Conclusion: These findings corroborate existing literature on surfactant-mediated hematotoxicity. They also provide novel insights into the quantitative hematological changes induced by a commercially prevalent detergent formulation. The results demonstrated the need for enhanced safety protocols and public health advisories regarding household chemical exposure, particularly in pediatric and domestic or pets and animal contexts where accidental ingestion risks are elevated.

Key words: RRed blood cells (RBCs), Hematotoxicity, Detergent exposure, Viva Plus, Albino rats, Hematology


 
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How to Cite this Article
Pubmed Style

Gwiokura AY, Maina UA, Adawaren EO. Hematological Changes in Albino Rats Following Subacute Exposure to Viva Plus Detergent: Implications for Household Chemical Safety. J Exp Lab Med. 2025; 2(4): 169-175. doi:10.5455/JELM.20250814051736

Web Style

Gwiokura AY, Maina UA, Adawaren EO. Hematological Changes in Albino Rats Following Subacute Exposure to Viva Plus Detergent: Implications for Household Chemical Safety. https://www.wisdomgale.com/jelm/?mno=277406 [Access: December 11, 2025]. doi:10.5455/JELM.20250814051736

AMA (American Medical Association) Style

Gwiokura AY, Maina UA, Adawaren EO. Hematological Changes in Albino Rats Following Subacute Exposure to Viva Plus Detergent: Implications for Household Chemical Safety. J Exp Lab Med. 2025; 2(4): 169-175. doi:10.5455/JELM.20250814051736


Vancouver/ICMJE Style

Gwiokura AY, Maina UA, Adawaren EO. Hematological Changes in Albino Rats Following Subacute Exposure to Viva Plus Detergent: Implications for Household Chemical Safety. J Exp Lab Med. (2025), [cited December 11, 2025]; 2(4): 169-175. doi:10.5455/JELM.20250814051736


Harvard Style

Gwiokura, A. Y., Maina, . U. A. & Adawaren, . E. O. (2025) Hematological Changes in Albino Rats Following Subacute Exposure to Viva Plus Detergent: Implications for Household Chemical Safety. J Exp Lab Med, 2 (4), 169-175. doi:10.5455/JELM.20250814051736


Turabian Style

Gwiokura, Aliyu Yahaya, Umar Abdullahi Maina, and Emmanuel Oluwasegun Adawaren. 2025. Hematological Changes in Albino Rats Following Subacute Exposure to Viva Plus Detergent: Implications for Household Chemical Safety. Journal of Experimental and Laboratory Medicine, 2 (4), 169-175. doi:10.5455/JELM.20250814051736


Chicago Style

Gwiokura, Aliyu Yahaya, Umar Abdullahi Maina, and Emmanuel Oluwasegun Adawaren. "Hematological Changes in Albino Rats Following Subacute Exposure to Viva Plus Detergent: Implications for Household Chemical Safety." Journal of Experimental and Laboratory Medicine 2 (2025), 169-175. doi:10.5455/JELM.20250814051736


MLA (The Modern Language Association) Style

Gwiokura, Aliyu Yahaya, Umar Abdullahi Maina, and Emmanuel Oluwasegun Adawaren. "Hematological Changes in Albino Rats Following Subacute Exposure to Viva Plus Detergent: Implications for Household Chemical Safety." Journal of Experimental and Laboratory Medicine 2.4 (2025), 169-175. Print. doi:10.5455/JELM.20250814051736


APA (American Psychological Association) Style

Gwiokura, A. Y., Maina, . U. A. & Adawaren, . E. O. (2025) Hematological Changes in Albino Rats Following Subacute Exposure to Viva Plus Detergent: Implications for Household Chemical Safety. Journal of Experimental and Laboratory Medicine, 2 (4), 169-175. doi:10.5455/JELM.20250814051736


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