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Clinical Practice Article
Online Published: 20 Apr 2024


A clinico-pathological analysis of Ivermectin-induced toxicity in eight Hermann’s Tortoises treated for tick infestation

Abdulhakeem Binhambali, Musa Halidu, Dauda Dauda Ibrahim, Zainab Oyiza Idris, Raji Bolaji Abdulsallam, Raphael Omerah Attah.


Cited By:1

Abstract
This study presents a clinico-pathological examination of ivermectin-induced toxicity in eight Hermann's tortoises, administered to address tick infestation. Subsequently, nervous signs were observed, leading to the demise of five tortoises. Clinical manifestations included inappetence, weakness, diarrhea, tremors, and paralysis preceding death. Postmortem examination revealed hemorrhagic lung tissues, fatty liver, and significant tick infestation. Laboratory analysis detected Borrelia spp. in blood smears, Oxyuris spp. eggs and cysts in fecal samples, and Escherichia coli and Salmonella enterica in microbial cultures. Histopathological analysis indicated hepatic vacuolar degeneration. The correlation between clinical, pathological, and histopathological findings suggests acute infection and drug toxicity, particularly ivermectin toxicity. The tortoises, initially weighing an average of 900 grams, were pets at Niger Resort Minna and were presented to the Nigerian Police Veterinary Hospital, Garki 2 on the 27th of May 2023, after exhibiting symptoms of inappetence and severe diarrhea following the administration of 1% ivermectin (Ivanor from Jubaili Animal Health Ltd) at a dose rate of 0.04 mg/kg. Three tortoises died shortly after administration, with two succumbing within hours.

Key words: Ivermectin toxicity, Hermann's tortoise, Tick infestation, pathology, Hepatic vacuolar degeneration.


 
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How to Cite this Article
Pubmed Style

Binhambali A, Halidu M, Ibrahim DD, Idris ZO, Abdulsallam RB, Attah RO. A clinico-pathological analysis of Ivermectin-induced toxicity in eight Hermann’s Tortoises treated for tick infestation. J Res Vet Sci. 2024; 2(3): 125-134. doi:10.5455/JRVS.20240328090505

Web Style

Binhambali A, Halidu M, Ibrahim DD, Idris ZO, Abdulsallam RB, Attah RO. A clinico-pathological analysis of Ivermectin-induced toxicity in eight Hermann’s Tortoises treated for tick infestation. https://www.wisdomgale.com/jrvs/?mno=195754 [Access: April 22, 2025]. doi:10.5455/JRVS.20240328090505

AMA (American Medical Association) Style

Binhambali A, Halidu M, Ibrahim DD, Idris ZO, Abdulsallam RB, Attah RO. A clinico-pathological analysis of Ivermectin-induced toxicity in eight Hermann’s Tortoises treated for tick infestation. J Res Vet Sci. 2024; 2(3): 125-134. doi:10.5455/JRVS.20240328090505


Vancouver/ICMJE Style

Binhambali A, Halidu M, Ibrahim DD, Idris ZO, Abdulsallam RB, Attah RO. A clinico-pathological analysis of Ivermectin-induced toxicity in eight Hermann’s Tortoises treated for tick infestation. J Res Vet Sci. (2024), [cited April 22, 2025]; 2(3): 125-134. doi:10.5455/JRVS.20240328090505


Harvard Style

Binhambali, A., Halidu, . M., Ibrahim, . D. D., Idris, . Z. O., Abdulsallam, . R. B. & Attah, . R. O. (2024) A clinico-pathological analysis of Ivermectin-induced toxicity in eight Hermann’s Tortoises treated for tick infestation. J Res Vet Sci, 2 (3), 125-134. doi:10.5455/JRVS.20240328090505


Turabian Style

Binhambali, Abdulhakeem, Musa Halidu, Dauda Dauda Ibrahim, Zainab Oyiza Idris, Raji Bolaji Abdulsallam, and Raphael Omerah Attah. 2024. A clinico-pathological analysis of Ivermectin-induced toxicity in eight Hermann’s Tortoises treated for tick infestation. Journal of Research in Veterinary Sciences, 2 (3), 125-134. doi:10.5455/JRVS.20240328090505


Chicago Style

Binhambali, Abdulhakeem, Musa Halidu, Dauda Dauda Ibrahim, Zainab Oyiza Idris, Raji Bolaji Abdulsallam, and Raphael Omerah Attah. "A clinico-pathological analysis of Ivermectin-induced toxicity in eight Hermann’s Tortoises treated for tick infestation." Journal of Research in Veterinary Sciences 2 (2024), 125-134. doi:10.5455/JRVS.20240328090505


MLA (The Modern Language Association) Style

Binhambali, Abdulhakeem, Musa Halidu, Dauda Dauda Ibrahim, Zainab Oyiza Idris, Raji Bolaji Abdulsallam, and Raphael Omerah Attah. "A clinico-pathological analysis of Ivermectin-induced toxicity in eight Hermann’s Tortoises treated for tick infestation." Journal of Research in Veterinary Sciences 2.3 (2024), 125-134. Print. doi:10.5455/JRVS.20240328090505


APA (American Psychological Association) Style

Binhambali, A., Halidu, . M., Ibrahim, . D. D., Idris, . Z. O., Abdulsallam, . R. B. & Attah, . R. O. (2024) A clinico-pathological analysis of Ivermectin-induced toxicity in eight Hermann’s Tortoises treated for tick infestation. Journal of Research in Veterinary Sciences, 2 (3), 125-134. doi:10.5455/JRVS.20240328090505




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