Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams

Foluso Bolawaye Bolaji-alabi; Tomiwa Samuel Ojo; Onaopemipo Oluwaseun Fabunmi; Babatola Olayinka Fabiyi; Shakirat Omolara Adediran

doi:10.5455/JRVS.20260513100043

J Res Vet Sci. 2026; 6(3): 246-259

doi: 10.5455/JRVS.20260513100043

Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams

Foluso Bolawaye Bolaji-alabi, Tomiwa Samuel Ojo, Onaopemipo Oluwaseun Fabunmi, Babatola Olayinka Fabiyi, Shakirat Omolara Adediran.

Abstract
Aim: The aim of the study was to evaluate the sedative, analgesic, cardiorespiratory, and haematological effects of intravenous midazolam-pentazocine (MP) and diazepam-pentazocine (DP) combinations in healthy West African Dwarf (WAD) rams.
Methods: Six healthy male WAD rams (average 14.0 ± 2.0 kg) participated in a randomised crossover trial with a 7-day washout period. Protocol MP involved midazolam (0.6 mg/kg) plus pentazocine (0.5 mg/kg), while Protocol DP used diazepam (0.3 mg/kg) plus pentazocine (0.5 mg/kg).
Results: Both combinations induced rapid, profound sedation and analgesia within 10 minutes, achieving maximum scores of 4/4. Cardiorespiratory parameters, including heart rate, respiratory rate, rectal temperature, mean arterial pressure, and oxygen saturation, remained stable for 90 minutes in both groups, with no significant differences except for baseline respiratory rate. Haematological analysis showed no significant changes within or between groups, indicating minimal haematotoxicity. Notably, the MP group recovered significantly faster at 80–90 minutes post-administration, with lower sedation (1.0 ± 0.6 against 1.7 ± 0.8) and analgesia (1.8 ± 0.4 against 2.3 ± 1.0) scores than the DP group.
Conclusion: Both midazolam-pentazocine and diazepam-pentazocine protocols proved safe and effective for short-term sedation in West African Dwarf rams, though midazolam-pentazocine is preferable for quicker recovery, while diazepam-pentazocine suits procedures requiring longer restraint.
Keywords: Midazolam, Diazepam, Pentazocine, West African Dwarf rams, Sedation

Key words: Midazolam, Diazepam, Pentazocine, West African Dwarf rams, Sedation

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How to Cite this Article

Pubmed Style

Bolaji-alabi FB, Ojo TS, Fabunmi OO, Fabiyi BO, Adediran SO. Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams. J Res Vet Sci. 2026; 6(3): 246-259. doi:10.5455/JRVS.20260513100043

Web Style

Bolaji-alabi FB, Ojo TS, Fabunmi OO, Fabiyi BO, Adediran SO. Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams. https://www.wisdomgale.com/jrvs/?mno=320759 [Access: July 30, 2026]. doi:10.5455/JRVS.20260513100043

AMA (American Medical Association) Style

Bolaji-alabi FB, Ojo TS, Fabunmi OO, Fabiyi BO, Adediran SO. Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams. J Res Vet Sci. 2026; 6(3): 246-259. doi:10.5455/JRVS.20260513100043

Vancouver/ICMJE Style

Bolaji-alabi FB, Ojo TS, Fabunmi OO, Fabiyi BO, Adediran SO. Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams. J Res Vet Sci. (2026), [cited July 30, 2026]; 6(3): 246-259. doi:10.5455/JRVS.20260513100043

Harvard Style

Bolaji-alabi, F. B., Ojo, . T. S., Fabunmi, . O. O., Fabiyi, . B. O. & Adediran, . S. O. (2026) Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams. J Res Vet Sci, 6 (3), 246-259. doi:10.5455/JRVS.20260513100043

Turabian Style

Bolaji-alabi, Foluso Bolawaye, Tomiwa Samuel Ojo, Onaopemipo Oluwaseun Fabunmi, Babatola Olayinka Fabiyi, and Shakirat Omolara Adediran. 2026. Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams. Journal of Research in Veterinary Sciences, 6 (3), 246-259. doi:10.5455/JRVS.20260513100043

Chicago Style

Bolaji-alabi, Foluso Bolawaye, Tomiwa Samuel Ojo, Onaopemipo Oluwaseun Fabunmi, Babatola Olayinka Fabiyi, and Shakirat Omolara Adediran. "Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams." Journal of Research in Veterinary Sciences 6 (2026), 246-259. doi:10.5455/JRVS.20260513100043

MLA (The Modern Language Association) Style

Bolaji-alabi, Foluso Bolawaye, Tomiwa Samuel Ojo, Onaopemipo Oluwaseun Fabunmi, Babatola Olayinka Fabiyi, and Shakirat Omolara Adediran. "Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams." Journal of Research in Veterinary Sciences 6.3 (2026), 246-259. Print. doi:10.5455/JRVS.20260513100043

APA (American Psychological Association) Style

Bolaji-alabi, F. B., Ojo, . T. S., Fabunmi, . O. O., Fabiyi, . B. O. & Adediran, . S. O. (2026) Comparative Evaluation of Midazolam-pentazocine and Diazepam-pentazocine for Sedation and Analgesia In West African Dwarf Rams. Journal of Research in Veterinary Sciences, 6 (3), 246-259. doi:10.5455/JRVS.20260513100043